Wei Shi

Wei Shi

Assistant Professor of Chemistry (Organic)


Room:CP 305

Johns Hopkins School of Medicine (Postdoc) 
University of Alberta (Ph.D.) 
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Research Interests

Dr. Shi's research is in the application of organic and medicinal chemistry to explore biological and pharmaceutical potential of underexplored bioactive natural products, in particular glycoconjugates. The long-term goal of his laboratory is to design new chemical entities derived from the natural products with an improved synthetic and/or therapeutic profile for drug discovery. For more current information, please check his group website listed above.

Selected Publications
(Corresponding author denoted by *; Undergraduate denoted by §)
Zong, G.†; Hu, Z.†; O'Keefe, S.;# Tranter, D.;# Iannotti, M. J.;# Baron, L.;# Hall, B.;# Corfield, K.;# Paatero, A.; Henderson, M. J.;# Roboti, P.;# Zhou, J.; Sun, X.; Govindarajan, M.; Rohde, J.; Blanchard, N.; Simmonds, R.;* Inglese, J.;* Du, Y.;* Demangel, C.;* High, S.;* Paavilainen, V. O.;* Shi, W. Q.* “Ipomoeassin F binds Sec61α to inhibit protein translocation”, J. Am. Chem. Soc. 2019, 141, 8450–8461. (†, # Equal contribution)
Zong, G.; Sun, X.; Bhakta, R.§; Whisenhunt, L.; Hu, Z.; Wang, F.; Shi, W. Q.* “New insights into structure–activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues”, Eur. J. Med. Chem. 2018144, 751–757.
Zong, G.†; Hirsch, M.†; Mondrik, C.§; Hu, Z.; Shi, W. Q.* “Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F”, Bioorg. Med. Chem. Lett. 201727, 2752–2756. († Equal contribution)
Head, S.; Shi, W. Q.; Yang, E. J.; Nacev, B. A.; Hong, S. Y.; Pasunooti, K.; Li, R. J.; Shim, J. S.; Liu, J. O.* “Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis”, ACS Chem. Biol. 2017, 22, 174–182.
Zong, G.; Whisenhunt, L.; Hu, Z.; Shi, W. Q.* “Synergistic contribution of tiglate and cinnamate to cytotoxicity of ipomoeassin F”, J. Org. Chem. 2017, 82, 4977−4985.
Zong, G.; Aljewari, H.; Hu, Z.; Shi, W. Q.* “Revealing the pharmacophore of ipomoeassin F through molecular editing”, Org. Lett. 2016, 18, 1674−1677.
Zong, G.; Barber, E.; Aljewari, H.; Zhou, J.; Hu, Z.; Du, Y.; Shi, W. Q.* “Total synthesis and biological evaluation of ipomoeassin F and its unnatural 11R-epimer” J. Org. Chem. 2015, 80, 9279−9291.
Head, S.; Shi, W.; Zhao, L.; Gorshkov, K.; Pasunooti, K.; Chen, Y.; Deng, Z,; Li, R.; Shim, J. S.; Tan, W.; Hartung, T.; Zhang, J.; Zhao, Y.; Colombini, M.; Liu, J. O.* “The antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells”, Proc. Natl. Acad. Sci. U.S.A. 2015, 112, E7276–7285.
Shi, W.; Nacev, B. A.; Aftab, B.; Head, S.; Rudin, C. M.; Liu, J. O.* “Itraconazole side chain analogs: structure–¬¬activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and Hedgehog signaling” J. Med. Chem. 201154, 7363–7374.
Shi, W.; Marcus, S. L.; Lowary, T. L.* “Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem. 2011, 19, 603–612.
Shi, W.; Nacev, B. A.; Bhat, S.; Liu, J. O.* “Impact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole” ACS Med. Chem. Lett. 2010, 1, 155–159.
Shi, W.; Coleman, R. S.; Lowary, T. L.* “Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics” Org. Biomol. Chem. 2009, 7, 3709–3722.
Shi, W.; Qian, X.;* Zhang, R.; Song, G. “Synthesis and quantitative structure–activity relationships of new 2,5-disubstituted-1,3,4-oxadiazoles” J. Agric. Food Chem. 2001, 49, 124–130.