Professor Emeritus of Chemistry
University of California Riverside Ph.D. (1975)
University of Washington M.S. (1970)
University of California Santa Cruz B.A. (1969)
Trace metal nutrient biochemistry often differs markedly from the biochemistry of the major nutrients (e.g. carbohydrates or amino acids). Currently, our laboratory is focused on the unique aspects of membrane transport for the trace metals. We are studying the impact of lipid bilayer changes on zinc ion transport. Lipid oxidation greatly increases transmembrane zinc movement. We use two experimental systems: (1) model lipid vesicles containing high performance liquid chromatography-purified oxidized lipids and a chromophoric chelator to indicate zinc transport via ultraviolet/visible light spectroscopy; (2) human erythrocytes containing a chelator which yields a nuclear magnetic resonance signal upon zinc transport. In addition, our research has led us to a parallel study of the environmental impact of oxidation on oysters in metal-polluted waters.
Scott E. Pattison, Scott Telles, Steve Friar, Cheri Stowell, Ryan Beckley, "Zinc Diffusion through Lipid Bilayers", Archives of Biochemistry and Biophysics, 351, 41-46 (1998).
Scott E. Pattison, Diana maniak, Steve Friar, "Cation Complexation by Anitpyryazo III: Chelate spectral Behavior Correlated with Divalent Cation Properties", Analytical Biochemistry, 247 181-183 (1997).