Bikram Sharma

Bikram Sharma

Assistant Professor of Biology

Phone:765-285-8817

Room:CL 171C


Dr. Bikram Sharma investigates the molecular processes that control cardiovascular development and regeneration. In addition to conducting this research, he also teaches undergraduate and graduate-level human physiology courses.

Sharma Lab Website

Education

Stanford University, Stanford, CA 
Postdoctoral Research Fellow (2013-2018)
Red-Horse Laboratory
Cardiovascular development

Indiana State University, Terre Haute, IN
Ph.D. (2009-2012)
Albig Laboratory
Biology (Physiology)

Ball State University, Muncie, IN
M.S. (2007-2009)
Biology (Biotechnology)

Hanover College, Hanover, IN
BA (2007)
Major: Biology
Minor: Chemistry

Research Interests

We are interested in understanding the details of cellular and molecular processes that guide cardiovascular development and regeneration. In particular, we want to characterize the cellular and molecular properties of embryonic progenitor stem cells of cardiovascular system and understand how they influence organogenesis and regeneration. 

Recent Publications

"A unique collateral artery development program promotes neonatal heart regeneration." Goldstone, A.B.*, Wang, H., Farry, J., D’Amato, G., Paulsen, M.J., Eskandari, A., Hironaka, C. E., Phansalkar, R., Sharma, B., Rhee, S., Shamskhou, E.A., Agalliu, D., de Jesus Perez. V., Woo, Y. J., Red-Horse, K. (2019) Cell 176, 1-15. (https://doi.org/10.1016/j.cell.2018.12.023).

"Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease." Rhee, S., Chung, JI., King, DA., D'Amato, G.,  Paik, DT., Duan, A., Chang, A., Nagelberg, D., Sharma, B., Jeong, Y., Diehn, M., Wu, JC., Morrison, AJ., and Red-Horse, K. Nature Comm. 2018 Jan 25;9(1):368 doi: 10.1038/s41467-017-02796-3. PMID:  29371594  (PDF)
 
"Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela-and Apj-Deficient Hearts." Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K. Dev Cell. 2017 Sep 25;42(6):655-666.e3. doi: 10.1016/j.devcel.2017.08.008. Epub 2017 Sep 7. PMID: 28890073 (PDF)
*Chosen for journal cover

"Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose lowering effects." Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ. Sci Transl Med. 2017 Sep 13;9(407). pii: eaad4000. doi: 10.1126/scitranslmed.aad4000. PMID: 28904225 (PDF)
*Chosen for journal cover

"Coronary Artery Development: Progenitor Cells and Differentiation Pathways." Sharma B, Chang A, Red-Horse K. Annu Rev Physiol. 2017 Feb 10;79:1-19. doi: 10.1146/annurev-physiol-022516-033953. Epub 2016 Dec 9. Review. PMID: 27959616 (PDF)

"Notch: A multi-functional integrating system of microenvironmental signals." LaFoya B, Munroe JA, Mia MM, Detweiler MA, Crow JJ, Wood T, Roth S, Sharma B, Albig AR. Dev Biol. 2016 Oct 15;418(2):227-41. doi: 10.1016/j.ydbio.2016.08.023. Epub 2016 Aug 24. Review.PMID: 27565024 (PDF)

Letter by Papangeli et al Regarding Article, "The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease." Papangeli I, Sharma B, Chun HJ. Circulation. 2015 Jul 14;132(2):e16. doi: 10.1161/CIRCULATIONAHA.114.012494. PMID: 26169651
 
"The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis." Chen HI*, Sharma B*, Akerberg BN, Numi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K. Development. 2014 Dec;141(23):4500-12. doi: 10.1242/dev.113639. Epub 2014 Nov 5. PMID: 25377552 (PDF)
* Co-first authorship

"Lumican exhibits anti-angiogenic activity in a context specific manner." Sharma B, Ramus MD, Kirkwood CT, Sperry EE, Chu PH, Kao WW, Albig AR. Cancer Microenviron. 2013 Dec;6(3):263-71. doi: 10.1007/s12307-013-0134-2. Epub 2013 Jun 18. PMID: 23775523 (PDF)

"Matrix gla protein reinforces angiogenic resolution." Sharma B, Albig AR. Microvasc Res. 2013 Jan;85:24-33. doi: 10.1016/j.mvr.2012.10.005. Epub 2012 Oct 27. PMID: 23110920 (PDF)