October 10, 2019 3:30 p.m.End:
October 10, 2019 4:30 p.m.
Department of Physics and Astronomy
Quantitative Single Molecule Imaging in Live Cells
Professor Jing Liu | IUPUI
Abstract: As the advancement in optical microscopy has pushed our understanding about life science towards finer, deeper, and faster, the complexity of instrumentation, data, and analysis has dramatically increased. Over the past decade, the role of optical microscope has transferred from a descriptive tool to a quantitative approach; the quality and complexity of large-volume images generated from these state-of-art microscopes preclude conventional visual and manual analysis. Our group has recently integrated computer vision, neural networking, and machine learning into the image processing and analysis, and has developed a quantitative bioimge analysis software “CellQuantifier”. With this software and several home-built optical microscopes, we are especially interested in exploring the fundamental biophysical properties, such as spatiotemporal dynamics, mechanics, and landscape of individual molecules or proteins in live cells, therefore to facilitate the diagnosis, treatment, and prevention of cancers or other diseases.
Sponsored by the Department of Physics and Astronomy