Publish Date: Sunday, May 01, 2005
1197 Board #52 3:30 PM - 5:00 PM Medicine & Science in Sports & Exercise. 37(5) Supplement:S227-S228. Individuals with Type II diabetes are considered to have the equivalent risk for coronary heart disease (CHD) as a patient with established CHD. The National Cholesterol Education Program (NCEP) recommends a more intensive approach to therapy for individuals with Type II diabetes, many of who have multiple dyslipidemias. PURPOSE: To evaluate the combined effect of exercise and extended release ER niacin (Niaspan, KOS Pharmaceuticals Inc., Miami, FL) on changes in total cholesterol (TC) HDL-cholesterol, LDL-cholesterol, triglycerides (TG), and glucose (GLC). METHODS: Subjects were 9 men and 7 women (mean age 59.7±10 years) that had Type II diabetes and had not been exercising regularly. All had body composition and a blood lipid profile (all values as mg/dl) performed prior to and after a 16-week exercise program. All subjects completed 16 weeks of a supervised aerobic exercise program with net energy expenditure (EE) gradually increased for the first 8 weeks. Additionally, all subjects received ER niacin at a beginning dose of 500 mg for the first 4 weeks, with the dosage increased by 500 mg at weeks 5, 9, and 13. The mean net EE exceeded 1000 kcals/week for weeks 8-11, and exceeded 1200 kcals/week for weeks 12-16. RESULTS: Following the 16-week exercise program, LDL (132.6±11.1 to 118±9.5) and TG (143.6±15.8 to 122.4±11.4) significantly decreased and HDL (42.6±2.6 to 53.5±2.6) significantly increased. There were no significant changes in TC, GLC, body weight, and estimated body fat percentage. CONCLUSIONS: Subjects with Type II diabetes obtained favorable changes in their blood lipid profile following a 16-week program of regular exercise and treatment with ER niacin. All patients maintained appropriate glucose control during the course of the study. Supported by KOS Pharmaceuticals, Inc. ©2005 The American College of Sports Medicine
Presentation Detail
Author
Co-Presenter(s)
Narelle Humphries
Alvito Rego
Mitchell H. Whaley, FACSM
Michael Wegner, FACSM
Alvito Rego
Mitchell H. Whaley, FACSM
Michael Wegner, FACSM
Location
Nashville, TN
