| 1918 |
Born February 26, 1918 near Rochester, Indiana. |
| 1939 |
Earned A.B. from Indiana University Bloomington. |
| 1942 |
Earned M.D. from Indiana University School of Medicine. |
| 1943-1946 |
Served in the Air Corps in the United States Army during World War II, rising from a 1st rank lieutenant to captain. |
| 1946-1972 |
Established and ran a family medical practice in Bremen, Indiana. |
| 1952 |
Served as Marshall County Coroner. |
| 1956-1958 |
Served as member of the Indiana House of Representatives. |
| 1960-1972 |
Served as member of the Indiana House of Representatives. |
| 1965 |
Became minority leader of the Indiana House of Representatives. |
| 1967 - 1968 |
Served as vice chairman of the Legistlative Council for the Indiana House of Representatives. |
| 1967 - 1972 |
Served as Speaker of the Indiana House of Representatives. |
| 1968 |
Ran unsuccessfully for the Republican nomination for governor of Indiana. |
| 1972 |
Elected for first term as governor of Indiana. |
| 1974 |
Implemented Property Tax Relief Program. |
| 1976 |
Re-elected for his second term as governor of Indiana. |
| 1981-1985 |
Named the Lester Bibler Professor of Medicine at the Indiana University School of Medicine. |
| 1985 |
Confirmed as Secretary of Health and Human Services under President Ronald W. Reagan by the U.S. Senate (93-2) on December 13, 1985. |
| 1988 |
Otis Bowen's purposed Medicare Catastrophic Coverage Act H.R. 2470 signed into law (P.L. 100-360) on July 1, 1988. |
| 1989 |
Completed service as Secretary of Health and Human Services on January 20, 1989. |
| 2000 |
Completed his autobiography, entitled Doc: Memories from a Life in Public Service. |
| 2007 |
Papers of Dr. Otis R. Bowen open for research in the Ball State University Libraries; ceremonies held to honor donation of papers to Ball State University. |